For example, in one study, researchers investigated the mood elevating effects of silymarin, a collection of phytochemicals extracted from milk thistle. Bookmark the permalink. It is native to Mediterranean countries. Eighteen clinical trials of 1,088 participants were assessed. Milk thistle can cause an allergic reaction, including a severe, potentially life-threatening allergic reaction (anaphylaxis). As a result, researchers suggest that milk thistle may be a useful therapy for preventing or delaying bone loss in postmenopausal women (24, 25). Unauthorized use of these marks is strictly prohibited. Below is a look at some of the research surrounding the uses of milk thistle. 2021;142:112024. doi:10.1016/j.biopha.2021, Walsh JA, Jones H, Mallbris L, et al. Learn more about natural remedies for type 2 diabetes. Herbal product use by persons enrolled in the Hepatitis C Antiviral Long-Term Treatment Against Cirrhosis (HALT-C) Trial. Silymarin is believed to have antioxidant properties. People with diabetes should use caution. National Cancer Institute PDQ Integrative, Alternative, and Complementary Therapies Editorial Board. Its also used to protect the liver against toxins like amatoxin, which is produced by the death cap mushroom and is deadly if ingested (7, 8). The research on milk thistle's use in cancer patients is promising, although more research is needed to determine its benefits. 2019;33(6):1627-1638. doi:10.1002/ptr.6361. Epub 2013 Oct 14. However, the review's authors warned that the quality of the studies was poor and that more research is needed before milk thistle should be recommended for use. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Pharmacol Rev. Milk thistle is a popular herbal remedy that has been used for its therapeutic effects for centuries. Biomed Pharmacother. Scan J Gastroenterol. One human trial found it to work as well as fluoxetine to manage OCD symptoms. Copyright 1996-2023 Cerner Multum, Inc. Silymarin, an active component of milk thistle, may improve liver function and reduce symptoms of cirrhosis, or scarring of the liver. Call your doctor for medical advice about side effects. This prickly plant has distinctive purple flowers and white veins, which traditional stories say were caused by a drop of the Virgin Marys milk falling onto its leaves. Silibinin, a flavonoid derived from milk thistle (Silybum marianum), has been used as a hepato-protectant in the clinical treatment of liver diseases. and transmitted securely. Thus, more studies are needed to determine what dose and length of treatment are needed for specific liver conditions (2, 11, 12). People may also find it painful and worry about its effects on their appearance. Verywell Health's content is for informational and educational purposes only. Milk thistle is found throughout the eastern United States, California, South America, Africa, Australia, and Asia. However, evidence suggests that milk thistle extracts might be useful in the treatment of mood disorders. 2018;8:65-74. doi:10.2147/PTT.S169333. (silymarin) extract supplementation on antioxidant status and hs-CRP in patients with type 2 diabetes mellitus: a randomized, triple-blind, placebo-controlled clinical trial, Silymarin in type 2 diabetes mellitus: a systematic review and meta-analysis of randomized controlled trials, Botanicals and their bioactive phytochemicals for women's health, Silymarin and hepatocellular carcinoma: a systematic, comprehensive, and critical review, Silymarin (milk thistle extract) as a therapeutic agent in gastrointestinal cancer. People with diabetes often have high cholesterol. Effect of silymarin (milk thistle) on liver disease in patients with chronic hepatitis C unsuccessfully treated with interferon therapy: a randomized controlled trial. However, there are currently no human studies, so its effectiveness remains unclear. Below is a short list of 4 widely available and very affordable herbs with some serious natural health benefits for OCD sufferers: Before introducing milk thistle into your diet, new supplements or any other herbs for OCD for that matter you should consult your physician. In some cases it may be useful in treating these cancers, but studies have yet to fully demonstrate the safety and efficacy of milk thistle use. Users are advised to seek the advice of their physician or other qualified health care provider with any questions you may have regarding a medical condition. Milk thistle is sometimes used to treat skin conditions including mild psoriasis. Milk thistle is effective at naturally reversing toxicity in the body, including the harmful . National Center for Complementary and Integrative Health. Mayo Clinic does not endorse companies or products. It usually develops slowly over a number of years and causes weak and fragile bones that break easily, even after minor falls. NCCIH has provided this material for your information. Certain people should take precautions when using milk thistle, and others may need to avoid it altogether. Silibinin, a flavonoid derived from milk thistle (Silybum marianum), has been used as a hepato-protectant in the clinical treatment of liver diseases. Summary The active ingredients in milk thistle have been shown in animals to improve the effects of some cancer treatments. Taken in appropriate doses, oral use of milk thistle appears to be safe. Further, while liver-related mortality was significantly reduced by milk thistle, this was not seen in any of the high-quality trials. Summary Initial test-tube and animal studies have shown that milk thistle has some promising characteristics that could make it useful for protecting brain function. Data sources include IBM Watson Micromedex (updated 2 Apr 2023), Cerner Multum (updated 17 Apr 2023), ASHP (updated 10 Apr 2023) and others. An allergic reaction is more common in people who are allergic to other plants in the Asteraceae family, such as ragweed, daisies, marigolds and chrysanthemums. Do not give any herbal/health supplement to a child without medical advice. One particular area of interest is in milk thistle's ability to protect and perhaps restore the liver. BDNF-TrkB pathway mediates antidepressant-like roles of H. New insights into BDNF function in depression and anxiety. By using our site, you acknowledge that you have read and understand our. Neuroprotective potential of silymarin against CNS disorders: insight into the pathways and molecular mechanisms of action. Depression, Milk Thistle, Mood, Silibum Marianum (milk thistle), Silymarin. Mastron JK, Siveen KS, Sethi G, Bishayee A.Silymarin and hepatocellular carcinoma: a systematic, comprehensive, and critical review. 2016 Jul;41(7):1662-72. doi: 10.1007/s11064-016-1881-5. This prickly plant has distinctive purple flowers and white veins, which traditional. Finally, those with hormone-sensitive conditions, including certain cancers, may need to avoid using milk thistle. Ebrahimpour, K.; Gargari, B.; Mobasseri, M. et al. It's also proven useful in treating skin that's been damaged by radiation during breast cancer treatment. Medical research suggests that milk thistle, combined with traditional treatment, can improve diabetes. Call our friendly customer service team at 1-800-569-4994 Weekdays 9am-12:30pm and 1:30pm-5pm EST, Get health news, exclusive offers, and more. 2023 Jan 26;15:997054. doi: 10.3389/fnmol.2022.997054. Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat. Milk Thistle Tea: Benefits, Side Effects, and Dosage. While milk thistle has been traditionally used in pregnant and breastfeeding women, its safety is unknown. Effect of silymarin on biochemical indicators in patients with liver disease: systematic review with meta-analysis. Milk thistle has been used for a range of psychiatric disorders including methamphetamine abuse and obsessive compulsive disorder. Milk thistle is native to Europe and was introduced into North America by early colonists. Ask your doctor for advice. This article looks at the evidence to, Whats the life expectancy of someone with cirrhosis of the liver? Some animal studies have shown that milk thistle could be useful for reducing the side effects of cancer treatments (26, 27, 28). Int J Mol Sci. In reducing oxidative stress, milk thistle is believed to be neuroprotective by helping prevent decline in brain function. Song X, Zhou B, Cui L, Lei D, Zhang P, Yao G, Xia M, Hayashi T, Hattori S, Ushiki-Kaku Y, Tashiro SI, Onodera S, Ikejima T. Neurochem Res. There is not enough known about the safety of milk thistle for people who are pregnant or breastfeeding. Have direct benefits against prostate, breast, and certain cervical cancer cells. People mainly use the supplement to treat liver conditions. the unsubscribe link in the e-mail. People sometimes eat the stem and leaves of milk thistle in salads. Milk thistle may also be used for purposes not listed in this product guide. Prasad RR, Paudel S, Raina K, Agarwal R. Silibinin and non-melanoma skin cancers. We encourage you to discuss any decisions about treatment or care with your health care provider. Similar supplements to milk thistle include: Please talk with your healthcare provider about the best supplement for you. However, this review also noted that the quality of the studies was not very high, so more studies are needed before its possible to make any firm recommendations (44). Do not use different forms (tablets, liquid, extract, teas, etc) of milk thistle at the same time without medical advice. sharing sensitive information, make sure youre on a federal What Is Complementary, Alternative, or Integrative Health? Thats an alarmingly high percentage, leaving roughly 1.1 million people of the 2.2 million OCD sufferers in the United States seeking alternative treatment options (2) and natural remedies. It is not known whether milk thistle passes into breast milk or if it could harm a nursing baby. Effects of Silybum marianum (L.) Gaertn. Unable to load your collection due to an error, Unable to load your delegates due to an error. Some, but not all, milk thistle supplements are vegan. One of the active ingredients in milk thistle called silymarin is extracted from the plant's seeds. Milk thistle has been used to treat disorders of the liver and gallbladder for at least 2,000 years. This herb (also known as Silybum marianum) is native to the Mediterranean region. Milk thistle is an herbal remedy derived from the milk thistle plant, also known as Silybum marianum. 2020;34(6):1446-1454. doi:10.1002/ptr.6620. Call your doctor if the condition you are treating with milk thistle does not improve, or if it gets worse while using this product. J Diabetes Res. The Clearinghouse does not provide medical advice, treatment recommendations, or referrals to practitioners. 1998-2023 Mayo Foundation for Medical Education and Research (MFMER). . Healthline Media does not provide medical advice, diagnosis, or treatment. Someone please correct me if I'm wrong. Summary One study has shown that people taking milk thistle supplements experienced a decrease in the number of acne lesions on their body. Check out these best-sellers and special offers on books and newsletters from Mayo Clinic Press. It is possibly effective in diabetes and indigestion (). Satisfaction. de Avelar CR, Pereira EM, de Farias Costa PR, et al. If you take any medicines regularly, talk to your doctor before you start using milk thistle. Common Names:milk thistle, Mary thistle, holy thistle, Latin Names:Silybum marianum, synonym Carduus marianus. 2014;10(1):31-35. doi:10.17925/EE.2014.10.01.31. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. But the herb is also believed to be beneficial for other health issues. 2016;2016:5147468. doi:10.1155/2016/5147468, Dietz BM, Hajirahimkhan A, Dunlap TL, Bolton JL. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. This makes it very hard to establish a standard dose. 5 Brain Supporting Supplements Youll Want In Your Medicine, According to the International OCD Foundation, selective serotonin reuptake inhibitor (SSRI), UltraThistle, the highest potency milk thistle formula, Review on the Chemistry and Neuroprotective Effects of Silymarin. Borah A, Paul R, Choudhury S, Choudhury A, Bhuyan B, Das Talukdar A, Dutta Choudhury M, Mohanakumar KP. Milk thistle is promoted as a dietary supplement for . Accessed Oct. 30, 2020. 2 skintightspandex 3 yr. ago Ya idk I've taken milk thistle for liver health and I have anxiety independent of it Nootropicsfan 3 yr. ago Although rare, milk thistle may trigger a number of common and mild side effects. Milk thistle is most often used for various liver conditions, like hepatitis and fatty liver disease. Bookshelf About curcumin, it isn't usually a problem but if you're on IMAOs you may like to read a bit before taking high doses. Researchers believe that silymarin reduced the oxidative stress traditionally attributed with diabetes (7). Other uses not proven with research have included treating malaria, mushroom poisoning, spleen or gallbladder problems, menstrual problems, liver problems (such as hepatitis B or C), and other conditions. Is There a Reason Your Milk Thistle Isn't Working? 2017 Apr;42(4):1073-1083. doi: 10.1007/s11064-016-2141-4. Eur Endocrinol. 2014;11(2):167-74. doi:10.1900/RDS.2014.11.167, Rambaldi A, Jacobs BP, Gluud C. Milk thistle for alcoholic and/or hepatitis B or C virus liver diseases. OCD symptoms usually revolve around irrational fears, repeated thoughts, and compulsions. Available for Android and iOS devices. Written by Cerner Multum. Milk thistle may cause an allergic reaction in those with allergies to plants in the same family, like ragweed, chrysanthemum, marigold, and daisy. World J Gastroenterol. As a liver support and liver aid, milk thistle acts as a powerful liver cleanser by rebuilding liver cells, reducing liver damage and removing toxins from the body that are processed through the liver. Debra Rose Wilson, Ph.D., MSN, R.N., IBCLC, AHN-BC, CHT, The 10 Best Herbs for Liver Health: Benefits and Precautions, How to Get Rid of Acne: 14 Home Remedies for Pimples. Silymarin (Silybum marianum; SM), popularly known as milk thistle, is an extract that has been used for many centuries to treat liver diseases. Quality and active ingredients in supplements may vary widely from maker to maker. Can You Get Milk Thistle Naturally From Foods? Zargani M, Ramirez-Campillo R, Arabzadeh E. Pflugers Arch. 2020;37(4):1279-1301. doi:10.1007/s12325-020-01251-y, Seeff LB, Curto TM, Szabo G, et al. Multiple Myeloma vs. Leukemia: What Are the Differences? . 1. Abstract Depression is one of the most frequent psychiatric disorders of Alzheimer's disease (AD). Milk thistle can also be taken with cholesterol-lowering medications, like statins.
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