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Young is NFL-ready thanks to his fast . That stat line would be worth 259.6 points, not much different from the 260.1 points that Allen produced last season. Stat to know: The Niners' Jeff Wilson Jr. has scored multiple rushing touchdowns in two straight games. passing windows despite a smaller 5-foot-10, 204-pound frame. With a banged-up Steelers defense that has struggled since T.J. Watt's Week 1 injury, this game has the potential for any number of Buffalo offensive superlatives. They haven't lost three straight road games since 2018. Yes, he's 2-0, but the Saints will need more from Bridgewater, 1 p.m. NFL picks, predictions for Week 5 Los Angeles Rams (-1.5) at Seattle Seahawks Thursday, 8:20 p.m., FOX/NFL Network The NFC West grinder continues. Stat to know: Allen has accounted for all 12 of the Bills' offensive touchdowns this season (either pass or scored). Steelers 27, Jaguars 20 -- Jeremy Fowler, The Seahawks are coming off one of the more dominant halves of football they've played under Pete Carroll, outscoring the Colts 36-3 and holding them to 32 yards in the second half last week. Eli Manning beats Philip Rivers for the first time in his career. Get the latest NFL Week 5 picks from CBS Sports. But New York also hasn't faced a quarterback like Rodgers and has a pedestrian 9.0 sacks and a 29.0% pressure rate, per NFL Next Gen Stats. ESPN Fantasy's Kyle Soppe and ESPN Chalk's Mackenzie Kraemer hand out helpful nuggets as well. FPI prediction: LAC, 57.5% (by an average of 2.3 points), Matchup must-reads: Chargers hope to get on track Browns' schedule gets difficult from now on Garrett back at Browns practice for first time since car crash, What to watch for: It looks like another week without Winston and wide receiver Michael Thomas, which would mean Andy Dalton will likely take over again at quarterback. See Week 5 rankings. NFL expert picks, predictions, lines for Week 5 highlighted by the Giants at Green Bay, Dallas at the Rams, and Las Vegas at Kansas City NFL Expert Picks, Predictions: Week 5 * next to the pick means the team will win, but not cover. Betting nugget: Philadelphia is 10-0 all time against New York and 9-1 ATS. Sidney Jones (hamstring) has practiced this week in hopes of playing. The Saints, meanwhile, have committed an NFL-high 11 turnovers -- including five interceptions in three games from Jameis Winston -- so the opportunity will be there. NFL Week 5 Early Odds, Picks & Predictions (2022) by Jason Radowitz | Sep, 29 2022 Before Week 4 begins, there's plenty of value with some Week 5 lines. Read more. Another big day could be in store for Bosa here, and don't be surprised if he brings back the "flag plant" celebration he used against Mayfield in that previous meeting. See Week 5 rankings. This has the makings of another close loss. The Bills' offense -- which has gone three-and-out on 48 percent of drives this season, second most in the NFL -- will be playing short-handed at wide receiver because of a thumb injury to No. But can the Colts keep possession effectively enough to pull the upset? That doesnt mean theyll have an easy time against Houston rookie QB Deshaun Watson. It ranks in the bottom third of the NFL in yards allowed per carry (5.0), and the Giants -- with the NFL's leading rusher, Saquon Barkley -- run it at the second-best clip in the league (5.8 yards per carry). Vikings 20, Bears 17 -- Courtney Cronin, The Bears are 14-2 in their past 16 home games against the Vikings dating back to the 2001 season. 1 overall pick, are hours away from being on the clock -- which means the 2023 NFL draft has arrived. But this will be an emotional weekend at Lucas Oil Stadium for the Colts. -- Rich Cimini. So it is possible things don't get better for Stafford this week. -- Rich Cimini, Bold prediction: Bridgewater with throw for 300 yards and three touchdowns, including two to Tyreek Hill. Additionally, the Eagles are averaging a league-high 8.79 passing yards per play while the Cardinals are giving up 7.36, which ranks 25th in the league. NFL Week 5 picks, predictions: Who wins each Week 5 NFL game? Betting nugget: This game has the highest over/under this season. See Week 5 rankings. Irrelevant' pick on Toledo's Johnson, Chargers go all-in on TCU with Duggan pick in 7th, 10 fantasy football breakout players for 2023, Will Levis opens up about emotional draft day, Steelers' first draft under Omar Khan was 'aggressive' and achieved high marks, After hoopla of going No. NFL picks against the spread for Week 5. Matchup rating: 53.8 | Spread: TEN -3 (38.5), What to watch for: Marcus Mariota has not thrown an interception this season, but the Bills are tied with the Giants and 49ers for second in the NFL with five picks each. Stat to know: Tampa Bay's Shaquil Barrett leads the NFL with 9.0 sacks through four games. Without Tyreek Hill, Chiefs' receiving load shifting to tight ends and backs Patrick Mahomes says Andy Reid 'stole the show' in TV ad, 9:30 a.m. He is leading the NFL in sacks and pressures this year. What's more, it's Mayfield at quarterback for the Panthers this time, the same signal-caller Bosa made a point of terrorizing in 2019 with two sacks, a forced fumble and a fumble recovery. What to know for fantasy: Jameis Winston has thrown three-plus touchdown passes in consecutive games for the first time in his career, but now he gets a Saints team against which he has never thrown three-plus touchdown passes in a game. -- Jamison Hensley, Bold prediction: Ja'Marr Chase will have more than 125 receiving yards. Bold prediction: With quarterback Sam Darnold (mono) sidelined for a third straight game, the Jets' epic struggles on offense will continue. Moody's pick: 49ers 27, Panthers 10 Watch the latest episode, Bold prediction: Cleveland running back Nick Chubb rushes for more than 100 yards against San Francisco's No. FPI prediction: CAR, 57.9% (by an average of 2.8 points), Matchup must-reads: Fournette flourishes in Christian McCaffrey-type workload Amid defensive changes, Kuechly remains the Panthers' stopper Jaguars looking to cash in on Minshew mania Khan: No plan to trade CB Jalen Ramsey, 1 p.m. Expect the Texans to feed the Jaguars a heavy dose of Pierce, especially with run-game anchor Foley Fatukasi dealing with a quad injury. Swift likely out again vs. Patriots, source says, What to watch for: The Vikings' defense has given up 1,054 passing yards this season, seventh-most in the NFL, as it meanders through the adjustment process to coordinator Ed Donatell's 3-4 scheme. DiRocco's pick: Panthers 17, Jaguars 16 Jets' high-priced, underperforming offensive line receives wake-up call Eagles RBs coach Duce Staley: 'A lot of Jordan and a lot of Miles', 1 p.m. Josh McCown has completed 75 percent of his passes against the blitz, which bodes well against the blitz-heavy Browns, who have allowed a 127 passer rating when blitzing. Betting nugget: Detroit has covered six straight road games, but it is 0-10-1 outright in its past 11 road games (0-9-1 under Dan Campbell). See Week 5 rankings. Moody's pick: Cowboys 23, Rams 20 Through four games, they have collected an NFL-low 390 passing yards -- the fourth fewest by any team at this point in a season since 2000. Read more. What to know for fantasy: Pittsburgh's Diontae Johnson owns a 20.5% target share this season from Rudolph, up from his 9.7% rate with Ben Roethlisberger under center. Betting nugget: The past four times Jacksonville was a favorite, it lost the game outright, with three of those losses coming against Houston. Read more. Walder's pick: Packers 24, Giants 12 The Patriots have allowed a league-high five touchdowns to tight ends this season. See Week 5 rankings. The 49ers are tied for second in the NFL in sacks with 15 -- which is not a good omen for Mayfield. Week 5 NFL predictions: Scores for every game - NFL Nation- ESPN What to know for fantasy: After scoring 11 times in his first 14 games last season, Hopkins has scored just twice in his past seven games (playoffs included). On the other side of the ball, Tom Brady said his shoulder is fine, but former Falcon Julio Jones' status is up in the air after missing the second half last week because of a knee injury. 1-ranked run defense to power the Browns to their second win on Monday Night Football this season. Finally, Seth Walder and Eric Moody give us final score picks for every game. See Week 5 rankings. See Week 5 rankings. The Graham mistake 2.0: TE a rare miss for Packers GM With Elliott next, Packers have to get run defense on track in a hurry Leighton Vander Esch's star rising as fast off field as on it For Randall Cobb, Packers game just another week, 8:20 p.m. But Browns RB Nick Chubb leads the NFL in rushing first downs and rushes of 10-plus yards. Betting nugget: Brandon Staley is 1-3 outright and ATS as a road favorite (won last week). FPI prediction: TEN, 74.0% (by an average of 8.9 points), Matchup must-reads: Taylor Lewan's return could be a boon for Titans' offense Allen progressing but still in protocol Gore closing on No. QB Teddy Bridgewater is 2-0 lifetime against the Jets, who look to go over .500 for the first time since a 1-0 start in 2018. But Joe Flacco's struggles (one touchdown in his past 28 drives) and Baltimore's poor history traveling out west (five consecutive losses) make it difficult to have any confidence in the Ravens. Read more. FPI prediction: MIN, 71.6% (by an average of 7.9 points), Matchup must-reads: Jones brings new energy, hope to Giants What's happened to Thielen and Diggs? Game of Midweek: Colts at Broncos (-3.5, 44 o/u) . UPDATE: I made seven changes to my final mock draft -- starting with the No. Russell Wilson's QBR in five road games against the Rams is 48.6 compared with 71.5 in his 37 other road games.

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