Yu P., Li Y.Z., Wan S.B., Wang Y. Efficacy of Lianhua Qingwen granules combined with abidor in the treatment of mild COVID-19. Wu et al. Modern pharmacological studies have shown that Lianhua Qingwen Prescription, as a traditional Chinese medicine prescription, has extensive antiviral and immunomodulatory effects on a series of influenza viruses. Plants of the World Online. Drugs and Clinic. Traditional Chinese medicine Lianhua Qingwen treating corona - PLOS The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. Cui L.F., Xu H.R., Li F.Z., Wang C.X. Meanwhile, the median effective concentrations (EC50) in above-mentioned effects were 0.042, 0.031, 0.051 and 0.050mg/mL, respectively, while the prevention effect on virus adsorption was the strongest [25]. Dr. Tan says that LianHua QingWen is not advisable for COVID patients who are experiencing a chilling sensation due to the infection. Compared with the conventional drug group, the incidence of disease recurrence was lower in the LHQW group, implied that LHQW might could regulate and enhance the immune function of the body. doi:10.1111/j.1365-2796.1990.tb00199.x, Higgins, J. P., Altman, D. G., Gtzsche, P. C., Jni, P., Moher, D., Oxman, A. D., et al. Potential publication bias was assessed using Funnel plot, Beggs and Eggers test. the Need for Accurate Scientific Nomenclature for Plants. Data were considered statistically significant at p values <0.05. Lianhua Qingwen(Forsythia suspensa (Thunb.) Cytokine storm is an excessive immune response of the body to external stimuli such as viruses, which will stimulate the secretion of a large number of inflammatory factors and lead to cytokine cascade reaction [4,6]. (Guanghuoxiang), Rheum palmatum L. (Dahuang), Rhodiola rosea Linn. No proven effective antiviral treatments for COVID-19 pneumonia are available at present (Ahsan et al., 2020; Cao et al., 2020; Chan et al., 2020; Khan et al., 2020; Kupferschmidt and Cohen, 2020). Royal Botanic Gardens, Kew science (2021). Figure 1 provides a detailed flowchart of the screening process. TABLE 2. CONTRAINDICATIONS Uncertainty. The following information was collected from each qualifying study: first authors name, year, treating disease, sample size, number of male and female, age, adverse reactions, dispose or outcome of adverse reactions. recently published a clinical study on the treatment of mild COVID-19 with LHQW granules (6g, tid) combined with abidor (0.2g, tid) [44]. (japanese honeysuckle) flower 27.41 mg, gypsu . Zhi-Hui Zhang and Wen-Cheng Zhou collected literatures and made the illustration. The incidence of nervous system damage was lower in the LHQW group compared to the conventional drug group (RR = 0.24, 95% CI = 0.180.32, p < 0.001). Impressively, LHQW in conjunction with conventional treatment could significantly improve COVID-19 patients as a synergetic strategy. MANILA, Philippines The Makati Medical Center's therapeutics and medication safety committee (TMSC) has said that the Chinese drug, Lianhua Qingwen (LQ), should not be taken without a doctor's prescription to ease new coronavirus disease (COVID-19) symptoms, warning that it may do more harm than good. Anti Covid-19 Drugs: Need for More Clinical Evidence and Global Action. doi:10.1016/s1043661802002104, Hallas, J., Harvald, B., Gram, L. F., Grodum, E., Brsen, K., Haghfelt, T., et al. 81703740), the Zhejiang Provincial Natural Science Foundation of China (No. Literature searching and extraction of data were done by CH, BH, FG, and ML. J. Nosocomiology. Keywords: Combination of western medicine and Chinese traditional patent medicine in treating a family case of COVID-19. 228 (2), 8390. On March 27, 2019, Yiling Pharmaceutical Co. Ltd. amended the LHQW drug manual to include adverse reactions related to its clinical application. Further evaluation revealed that LHQW significantly inhibited SARS-CoV-2 replication in Vero E6 cells, markedly reduced pro-inflammatory cytokines (TNF-, IL-6, CCL-2/MCP-1 and CXCL-10/IP-10) production and resulted in abnormal particle morphology of virion in cells [30]. Experimental study on prevention and treatment of influenza virus FM1 infection in mice by Lianhua Qingwen capsule. [4][10], In March 2022, during the Shanghai COVID-19 outbreak, the medication was distributed en masse to residents. While the results from our study showed that LHQW has a potentially reduced incidence of adverse reactions in certain diseases and symptoms to a greater extent than conventional treatment, efficacy is an important consideration that should not be overlooked. The majority of studies lacked sufficient description of allocation concealment and therefore, the project was predominantly evaluated as unclear risk of bias. Although the blinding method was not reported, since some symptom indicators needed measurement with instruments, assessment of symptom indicators was unlikely to be affected by the lack of blinding. doi:10.3969/j.issn.1672-2809.2020.13.020, Liu, C. Y., Li, X. Q., and Cai, S. Q. In a lipopolysaccharide (LPS)-induced acute lung injury animal model, LHQW could efficiently decrease the chemotaxis of monocytes toward the pulmonary infection foci, and thus blocked the disease development by down-regulating MCP-1 expression [33]. Mechanism by which ma-xing-shi-gan-tang inhibits the entry of influenza virus. LHQW has a reduced incidence of other adverse reactions compared to the conventional drug group (RR = 0.60, 95% CI = 0.430.84, p = 0.003). Traditional Chin. Furthermore, they identified two important metabolites, prostaglandin F2 and arachidonic acid, and their arachidonic acid metabolism pathway, as vital indicators of LHQW in treating influenza by using serum metabolomics analysis [19]. Therefore, it is essential to perform a systematic review and meta-analysis to assess the effect of Lianhua Qingwen combined with conventional antiviral Western Medicine in clinical treatment of COVID-19 or asymptomatic infection. Pharmacol. An article on telemedicine and medical news platform Dr. Lilac pointed out that there was no scientific evidence available to indicate that LHQW was effective as prophylaxis to prevent infection, nor did there exist any official government recommendation for such usage; instead, taking the drug unnecessarily carried a risk of side effects. The site is secure. LHQW was initially approved by the China Food and Drug Administration (CFDA) in 2004 and represents the first traditional Chinese medicine that passed the rapid drug approval channel of CFDA for treatment of severe acute respiratory syndrome (SARS). Progress on the efficacy and clinical application of Lianhua Qingwen capsule (LHQW). [Saururaceae; Houttuyniae Botanical drug], Rheum palmatum L. [Polygonaceae; Rhei Radix et Rhizoma] (Peng et al., 2015). government site. These in vitro studies indicate that LHQW shows a wide range of antiviral activities including its anti-SARS-CoV-2 role. Subgroup analysis revealed that LHQW group has a reduced incidence of rash than the conventional drug group (RR = 0.58, 95% CI = 0.390.86, p = 0.007), no statistical difference was detected for itchy skin. Exploring material basis and mechanism of Lianhua Qingwen prescription against coronavirus based on network pharmacology. ex DC. Twenty-six studies focused on treatment of common pneumonia, of which 23 reported adverse reactions. LQ15H280003), the Clinical Research Projects of Zhejiang Medical Association (No. This review has introduced the advances of LHQW in anti-viral treatment, intending to provide ideas for the timely treatment of COVID-19 patients. doi:10.26434/chemrxiv.12016236.v1. Wang et al. LHQW also decreased the influenza viral titers in the lungs of mice, with decreased inflammatory cytokine levels in the early stages of infection [24]. Available at: https://chemrxiv.org/engage/chemrxiv/article-details/60c74908ee301c485bc799cf (Accessed July 23, 2021). Efficacy and Safety of Lianhuaqingwen for Mild or Moderate Coronavirus Disease 2019. [8], Lianhua Qingwen has also been promoted and distributed by the government in Hong Kong (HK). As the Financial Times report showed, these appeared to be serious conflicts of interest as the investments benefited from the PRC and HK governments' rapid approval and then widespread national & international promotion of Lianhua Qingwen and other suspect treatments for purportedly helping COVID-19 sufferers. The official monograph of LHQW states that the adverse effects are "unclear". The collected evidence demonstrated that LHQW exhibited benefits against COVID-19. Ping F., Li Z., Zhang F., Li D., Han S. Effects of Lianhua Qingwen on pulmonary oxidative lesions induced by fine particulates (PM2.5) in rats. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). Inhibitorv Effect of Lianhua Oingwen Water Extract on Methicillin-Resistant staphylococcus Aureus Biofilm In Vitro. There was no statistically significant difference in the incidence of heart rate and arrhythmia between the LHQW group and the conventional drug group (RR = 0.67, 95% CI = 0.231.93, p = 0.454).
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