1981;19(3):245-249. 2020;12(2):e7083. Sedatives: Since ashwagandha can both energize and induce restorative sleep, it might negate or amplify the effect of other sedative drugs, especially the benzodiazepines. Take ashwagandha with these drugs only under your doctor's supervision, recommends the Langone Medical Center at New York University. Afewerky HK, Ayodeji AE, Tiamiyu BB, et al. Ashwagandha has also been used to increase performance among athletes and improve male infertility. Be aware that antidepressants and vitamins typically work with each other the vitamins won't replace your medication. 8 Warning Signs of Depression You Shouldn't Ignore, Depression in Adults With a Chronic Physical Health Problem: Treatment and Management, How Vegans Can Get All Their Nutrients (Without Taking Supplements), Complementary Therapies in Medicine Journal, 15 Celebrities Who Struggle With Anxiety and Depression, Australian Journal of Herbal Medicine: "B Vitamins Enhance Antidepressant Response in Adults", Open Neurology Journal: "Vitamin B12 Supplementation in Treating Major Depressive Disorder: A Randomized Controlled Trial", Journal of Psychiatry: "Adjunctive Nutraceuticals for Depression: A Systematic Review and Meta-Analyses", Mayo Clinic: "MAOIs and Diet: Is It Necessary to Restrict Tyramine? Nagashayana N, Sankarankutty P, Nampoothiri MRV, et al. Efficacy of Withania somnifera supplementation on adult's cognition and mood. If you're interested in taking a nutritional supplement to support your treatment for depression, talk to your doctor so you can find the one that works best for you and doesn't affect your antidepressants. Underactive Thyroid. St. John's wort can cause a buildup of serotonin in the body when taken with antidepressants. 2019;11(12):e6466. Mandlik Ingawale DS, Namdeo AG. Phytother.Res 2010;24(1):129-135. losartan, valsartan, telmisartan), Beta-Blockers (e.g. drugs for diabetes and blood pressure). Gopukumar K, Thanawala S, Somepalli V, Rao TSS, Thamatam VB, Chauhan S. Efficacy and safety of ashwagandha root extract on cognitive functions in healthy, stressed adults: a randomized, double-blind, placebo-controlled study. The average vitamin or mineral should not affect your antidepressant's functionality or your health. Withania somnifera, known as ashwagandha, has a role in ayurvedic medicine for a wide range of health conditions. It should not be confused with Physalis alkekengi, which is also referred to as winter cherry. 2021 Nov 25;13(2):100510. View abstract. If you consume something that isn't recommended, you could end up reducing the effectiveness of your medication or increasing the likelihood of side effects. Cancer Lett 2000;148:9-17. The Journal of Psychiatry study reported that omega-3 fats and vitamin D are the two essential nutrients that are most likely to help reduce depression symptoms. Some medications, such as those used after a transplant, decrease the activity of the immune system. The length of use of ashwagandha ranged from 14 to 110 days, and doses ranged from 450 milligrams to 1,350 milligrams per day. Cheah KL, Norhayati MN, Husniati Yaacob L, Abdul Rahman R. Effect of Ashwagandha (Withania somnifera) extract on sleep: A systematic review and meta-analysis. Therefore, it is recommended to consult with a healthcare professional before adding ashwagandha to a weight loss plan, especially if you have any underlying medical conditions or are taking any medications . Supplement use should be individualized and vetted by a healthcare professional, such as a registered dietitian, pharmacist, or healthcare provider. Association of l-DOPA with recovery following Ayurveda medication in Parkinson's Disease. Information from this source is evidence-based and objective, and without commercial influence. You can also connect with Dr. Brian Staiger on LinkedIn. Ashwagandha: ADHD Uses, Warnings, Side Effects, Dosage - MedicineNet 2022;15(9):1067-1080. doi:10.1080/17512433.2022.2121699, Salve J, Pate S, Debnath K, Langade D. Adaptogenic and anxiolytic effects of Ashwagandha root extract in healthy adults: a double-blind, randomized, placebo-controlled clinical study. One study, published in Phytotherapy Research, reported that ashwagandha supplementation reduced blood sugar and A1c levels, although this was a relatively small study. 1988;26(11):877-882. View abstract. National Center for Complementary and Integrative Health. 2019;11(10):2362. doi:10.3390/nu11102362, Zhu C, Zhang Y, Wang T, et al. Curr Sports Med Rep. 2017;16(4):230-239. doi:10.1249/JSR.0000000000000385. Xanax. Kulkarni RR, Patki PS, Jog VP, et al. Since you don't mention any drugs in your question, we'll list some of the potential interactions below. Drugs that cause sleepiness and drowsiness are called sedatives. View abstract. Influence of an Indian medicine (Ashwagandha) on acute-phase reactants in inflammation. No, that's not true all the time. 2019;11(12):e6466. Learn which supplements can interact with thyroid hormone medications like levothyroxine (Synthroid), thyroid hormone levels, and laboratory tests. A total of 0 drugs are known to interact with ashwaganda. Journal of Research in Ayurveda and Siddha 1980;1(2):247-258. However, tyramine-rich foods like cheeses, beer and other fermented products are dangerous for people taking MAOIs. Withania somnifera improves semen quality by regulating reproductive hormone levels and oxidative stress in seminal plasma of infertile males. However, certain vitamins, supplements and medications are processed via the same enzymatic pathway (cytochrome P450) as your antidepressants. This is called a medicine interaction. 2022;13(2):100510. doi:10.1016/j.jaim.2021.08.003, Gopukumar K, Thanawala S, Somepalli V, Rao TSS, Thamatam VB, Chauhan S. Efficacy and safety of Ashwagandha root extract on cognitive functions in healthy, stressed adults: a randomized, double-blind, placebo-controlled study. This holds true for ashwagandha. If you're taking antidepressants and vitamins at the same time, be aware of the ingredients in your vitamin supplements. What Vitamins Can You Not Take With Anti-Depressants? J Ayurveda Integr Med. Ashwagandha has mild interactions with at least 29 different drugs. Gupta, S. K., Dua, A., and Vohra, B. P. Withania somnifera (Ashwagandha) attenuates antioxidant defense in aged spinal cord and inhibits copper induced lipid peroxidation and protein oxidative modifications. ; Vomiting and nausea. First and foremost, I want to point out this it can tricky to determine whether or not a dietary/herbal supplement will interact with prescription drugs due to a general lack of studies on the matter. Always speak with a healthcare provider before taking a supplement to ensure that the supplement and dosage are appropriate for your individual needs. Ashwagandha is an evergreen shrub that grows in Asia and Africa. Khattak, S., Saeed, Ur Rehman, Shah, H. U., Khan, T., and Ahmad, M. In vitro enzyme inhibition activities of crude ethanolic extracts derived from medicinal plants of Pakistan. As with many other herbal supplements, little research is available on possible interactions. 2020;72:28-36. Some of the more compelling potential uses of ashwagandha are outlined below. View abstract. Additionally, ashwagandha may increase testosterone levels in the body. After 30 days, those who took either dose of ashwagandha self-reported positive effects on their anxiety. Am J Drug Alcohol Abuse 2009;35(1):1-11. Doses higher than that may interact with lexapro, or produce more pronounced effects. Tumori 8-31-1994;80(4):306-308. A recent study looked at the health claims and safety of ashwagandha and found that the herb has shown anticancer, anti-inflammatory, heart-protective, liver-protective, and immunomodulatory (able to change the immune system) actions. A 2020 case study examined five adults who had experienced signs of hepatotoxicity, or toxicity to the liver, after using ashwagandha in varying doses. For more information on drug interactions, visit the RxList Drug Interaction Checker. Its botanical name is Withania somnifera and it is also known as "Indian ginseng . Indian J Exp Biol. Indian J Physiol Pharmacol. Effect of Indian Ayurvedic medicine Ashwagandha on measurement of serum digoxin and 11 commonly monitored drugs using immunoassays: study of protein binding and interaction with Digibind. What Happens If I Take Too Much Ashwagandha? Adaptogenic Herbs And Their Interaction With Medications - Thyroid Nation Supplements that are similar to ashwagandha include: It's typically best to take just one supplement or herb at a time for a medical condition. Chronic stress increases cortisol levels, leading to lower levels of T3 and T4. Int.J.Crude Drug Res. Another traditional use of ashwagandha in Ayurveda is for memory issues. 2020;40(4):825-829. doi:10.1111/liv.14393, Siddiqui S, Ahmed N, Goswami M, Chakrabarty A, Chowdhury G. DNA damage by withanone as a potential cause of liver toxicity observed for herbal products ofWithania somnifera(ashwagandha). 2022 Mar 25;14(3):e23494. J Med Food 2022. This includes people who have had a transplant, are on chemo, or have an autoimmune disease. It's best to talk to your doctor before you start taking antidepressants and vitamins, especially mixed supplements. Does Ashwagandha supplementation have a beneficial effect on the management of anxiety and stress? View abstract. Change in balance, feeling shaky, or unsteady, Not able to think clearly or change in thinking, US Department of Defense Dietary Supplement Resource, https://www.opss.org/article/ashwagandha-dietary-supplement-products, This generalized information is a limited summary of diagnosis, treatment, and/or medication information. Herbal supplements and heart medicines may not mix - Mayo Clinic Arch Pathol Lab Med 2007;131:1298-303. Ashwagandha may help the body cope with stress. Since the effects of grapefruit juice may last as long as 3 days, it should be avoided if you are taking atorvastatin (Lipitor), lovastatin (Mevacor, Altoprev) or simvastatin (Zocor). Evaluation of the efficacy of withania somnifera (ashwagandha) root extract in patients with obsessive-compulsive disorder: a randomized double-blind placebo-controlled trial. Ashwagandha contains several active constituents including: The mechanism of how ashwagandha works, for all of its purported benefits, is not well understood. View abstract. Although ashwagandha is mainly considered safe, side effects may be possible. Always talk with a healthcare provider before starting any new supplement regimen. V. The effect of total alkaloids (ashwagandholine) on the central nervous system. There is no scientific evidence to support one supplement form over another, which means you should choose the one that best fits your lifestyle. View abstract. Tohda, C. [Overcoming several neurodegenerative diseases by traditional medicines: the development of therapeutic medicines and unraveling pathophysiological mechanisms]. Cureus. This means not enough is known about either the safety or effectiveness of taking daily ashwagandha for an extended period of time. doi:10.1002/brb3.1760, Adalier N, Parker H. Vitamin E, turmeric and saffron in treatment of Alzheimer's disease. Drug-induced hepatocellular injury due to herbal supplement ashwagandha. Ultimately, the supplements and foods you can . J Clin Psychiatry. J Funct Morphol Kinesiol. Ashwagandha - Diazepam Interaction Details | HelloPharmacist View abstract. It may cause you to become sleepy or drowsy. Devi, P. U., Sharada, A. C., Solomon, F. E., and Kamath, M. S. In vivo growth inhibitory effect of Withania somnifera (Ashwagandha) on a transplantable mouse tumor, Sarcoma 180. In rare cases, the use of ashwagandha may lead to liver damage. Bhattacharya SK, Satyan KS, Ghosal S. Antioxidant activity of glycowithanolides from Withania somnifera. The Best Brain Supplements For Cognitive Health - Forbes Is this an emergency? Supplements That Are Similar to Ashwagandha. The combination could result in excess thyroid hormone in the body, which has many negative effects. According to the Mayo Clinic, all of these SSRIs work by blocking the reuptake of serotonin in the brain, which essentially makes serotonin more available. Last updated on Feb 3, 2023. Ashwagandha: MedlinePlus Supplements The herb has been proven to interact with many other drugs, the interaction with SSRI (selective serotonin reuptake inhibitor) or Benzodiazepines are not proven scientifically. Are there any side effects of ashwagandha? 2021 Nov 30;2021:8254344. Ashwagandha Blood Pressure Medication Interaction View abstract. View abstract. This means they can cause drug-drug interactions, and they can have all the usual side effects and risks that pharmaceutical can have.